The most common agent is probably acetaminophen (Tylenol, although it is contained in many OTC medications). It remains the safest medication for fevers, aches, and pains, but only taken in small recommended amounts. Amounts greater than those recommended can result in liver damage or failure. Acetaminophen overdose is a common reason for considering a liver transplant.
A more serious problem occurs in patients who drink alcohol on a daily basis, particularly more than two drinks. In those situations, normal doses of Tylenol three to four times a day can produce severe liver damage. The same problem can occur in patients with the other liver diseases such as viral hepatitis. Additionally, more common toxins tend to be those that are inhaled, such as cleaning solvents, aerosolized paints, thinners, etc., which are more dangerous with an underlying condition.