The largest risk factor for liver disease from alcohol is the amount and the length of time the individual has been drinking. Males often develop complications that appear to be on a gender basis as well. Each individual is entirely different. Complication can develop after 5 to 10 years, though it more commonly it takes 20 to 30 years. Many individuals appear to never develop end stage liver disease from alcohol. This is impossible to predict ahead of time. And many other factors such as other diseases, hepatitis C, exposure to other toxins, as well as the individual’s own genetic make-up play a role.